Mahitosh Mandal

Thu, 4 Dec 2025 - 05:52

mypanel

Designation

Professor

Email

mahitosh@smst.iitkgp.ac.in

Dr. Mahitosh Mandal has made outstanding contribution in cancer research. He has identified specific genes and their biological functions in various cancers. In USA Lab., he has cloned Metastasis Associated gene 1 with ER-binding motif which stimulates malignant phenotypes. Also he discovered a link between telomerase activity and cancer progression. While at IIT, Kharagpur, he established a new Division of Cancer Biology where he has made significant contribution in developing newer targets for treatment and prevention of cancer. He showed that incorporation of an anti-EGFR molecule with VEGFR for chemotherapy can be more effective in treating patients with locally advanced or metastatic breast cancer. Mahitosh has also shown that Diacerein, an IL-6 inhibitor offered a novel blueprint for cancer therapy by hampering IL-6 /STAT3/MAPK/Akt network but without any toxic effects. Presently, he is engaged in nanoparticle mediated drug delivery and has shown that celecoxib-loaded Hap- Cht nanoparticles in colon cancer can serve as an effective and safe means of delivering the drug. Currently, he along with a team of oncologist, physicist and engineers are trying to determine specific molecular, bio-physical and bio-electrical changes in cancer cells during malignant transformation and acquisition of chemo-radioresistance. An outstanding contribution of Dr. Mandal as evidenced by majority of his publications in high impact factor Scopus indexed journals.

Research Areas:

Cancer Drug Discovery

Chemoresistance

Cell Signaling

Cancer Stem Cell

✓ Rajesh Y., Kumar U. , Mandal M., Heat Shock Proteins in Neuroscience, by Rajesh Y., Kumar U. , Mandal M., Therapeutic aspects of heat shock proteins in glioma: Cementing the crevasses between bench and bedside, 2019
✓ Majumder G. C., Roy N. , Mandal M. , Banerjee S., Anti-sticking factors and regulators of sperm motility, Anti-sticking factors and regulators of sperm motility, 193-210, 1992
✓ Majumder G. C., Mandal M. , Banerjee S, In Recent Advances in Animal Science Research, A Novel Sperm Motility-promoting Protein from Blood Serum and Its Applied Potential, 61-67, 2001
✓ Sarkar S., Mandal M., Breast Cancer: Classification Based on Molecular Etiology Influencing Prognosis and Prediction, Breast Cancer: Classification Based on Molecular Etiology Influencing Prognosis and Prediction, 69-84, 2011
✓ Parida S., Mandal M., Anti-Angiogenesis Drug Discovery and Development, Mechanism of Controlling Blood Vessel Growth and Development and Identification of Therapeutics Against Pathological Angiogenesis, 2014
✓ Banerjee K., Banerjee S. , Mandal M., Biological and Pharmaceutical Applications of Nanomaterials. Liposomes as a drug delivery system, Liposomes as a drug delivery system, 2015
✓ Rajesh Y., Mandal M., Proteases in Physiology and Pathology, Regulation of extracellular matrix remodeling and epithelial-mesenchymal transition by matrix metalloproteinases: decisive candidates in tumor progression, 154-159, 2017
✓ Biswas A., Yetirajam R. , Das S. , Parekh A. , Mandal M., Targeting ECM via stress associated regulation: A potential therapeutic avenue for overcoming temozolamide resistance in glioblastoma, European Congress on Biotechnology, 2018
✓ Das C. K., Jena B. C., Das S. , Parekh A. , Dey G. , Bharti R. , Bharadwaj D. , Mandal M., Parkin-mediated mitophagy regulates 5-fluorouracil-induced chemoresistance in breast cancer, AACR Annual Conference 2018 at Chicago, USA, 1348-1348, 2018
✓ Bharadwaj, D., Parekh A. , Das S. , Jena B. C., Mandal M., Polyploid giant cancer cells induce growth arrest and cytoskeletal rearrangement in breast cancer cells, European Congress on Biotechnology, 2018
✓ Jena B. C., Das C. K., Bharadwaj, D. , Das S. , Parekh A. , Mandal M., Tamoxifen resistance breast cancer induces mesenchymal phenotype in fibroblasts through TGF 1 signalling, European Congress on Biotechnology, 2018
✓ Das S., Jena B. C., Mundre S. , Parekh A. , Rajesh Y. , Mandal M, Integrin 1 regulates doxorubicin resistance in breast cancer via FAK-mediated activation of ERK1 pathway, Annual meeting of American Association of Cancer Research, 2018
✓ Kupferman M. E., Mandal M, Therapeutic suppression of constitutive and inducible JAK\STAT activation in head and neck squamous cell carcinoma, J Exp Ther Oncol, 117-127, 2009
✓ Mandal S. M., Mandal M. , Pati B. R, Proteomics view of a Rhizobium isolate response to arsenite [As(III)] stress, Acta Microbiol Immunol Hung, 157-167, 2009
✓ Mandal S. M., Mandal M. , Das A. K., Pati B. R., Ghosh A. K., Stimulation of indoleacetic acid production in a Rhizobium isolate of Vigna mungo, Arch Microbio, 389-393, 2009
✓ Jaganathan S. K., Mandal S. M., Jana S. K., Mandal M., Studies on the phenolic profiling, anti-oxidant and cytotoxic activity of Indian honey: in vitro evaluation, Nat Prod Res, 24, 2010
✓ Thalukder S., Mandal M. , Kundu S. C, Engineered silk fibroin protein 3D matrices for in vitro tumor model, Biomaterials, 2011
✓ Sarkar S., Mazumdar A. , Dash R. , Sarkar D. , Fisher P. B., Mandal M., ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells, J Cell Physiol, 375-384, 2011
✓ Rajput S., Mandal M., Antitumor promoting potential of selected phytochemicals derived from spices: a review, Eur J Cancer Prev, 205-215, 2012
✓ Rajput S., Kumar B. N., Sarkar S. , Fisher P. B., Mandal M., Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer, Plos One, 2013
✓ Sen K., Mandal M., Second generation liposomal cancer therapeutics: transition from laboratory to clinic, Int J Pharm, 28-43, 2013
✓ Choudhury H., Gorain B. , Dey G. , Mandal M. , Pal T. K., Improvement of cellular uptake, in vitro antitumor activity and sustained release profile with increased bioavailability from a nanoemulsion platform, Int J Pharm., 131-143, 2014
✓ Mahata D., Mandal S. M., Mandal M. , Nag A. , Nando G. B., Self-assembled cardanol azo derivatives as antifungal agent with chitin-binding ability, Int J Biol Macromol, 5-11, 2014
✓ Dey G., Bharti R. , Sen R. , Mandal M., Microbial amphiphiles: a class of promising new-generation anticancer agents, , 136-146, 2015
✓ Basak K., Dey G. , Sheet D. , Mahadevappa M. , Mandal M. , Dutta P. K, Probabilistic graphical modeling of speckle statistics in laser speckle contrast imaging for noninvasive and label-free retinal angiography, Conf Proc IEEE Eng Med Biol Soc, 2015
✓ Karthik, S., Kumar B. N., Gangopadhyay M. , Mandal M. , Pradeep N. D., A targeted, image-guided and dually locked photoresponsive drug delivery system, Journal of Materials Chemistry B, 728-732, 2015
✓ Banerjee K., Banerjee S. , Das S. , Mandal M., Probing the potential of apigenin liposomes in enhancing bacterial membrane perturbation and integrity loss, J Colloid Interface Sci., 48-59, 2015
✓ Kalita H., Kumar B. P., Konar S. , Tantubay S. , Mahto M. K., Mandal M. , Pathak A., Sonochemically synthesized biocompatible zirconium phosphate nanoparticles for pH sensitive drug delivery application, Materials Science and Engg:C (Mater. for Bio. Appl.
✓ Bhutia S. K., Behera B. , Mandal M. , Maiti T. K, Abrus agglutinin is a potent anti-proliferative and anti-angiogenic agent in human breast cancer, Int. J of Cancer, 457-466, 2016
✓ Biswas G., Jena B. C., Maiti S. , Samanta P. , Mandal M. , Dhara D., Photoresponsive Block Copolymer Prodrug Nanoparticles as Delivery Vehicle for Single and Dual Anticancer Drugs, ACS Omega, 6677-6690, 2017
✓ Sarkar S., Konar S. , Nagaprasad, P. , Shashi Rajputl S. , Kumar B. , Rao R. R., Mahanty A. (., Pathak, Paul B. Fisher, P. B., Mandal M, Micellear Gold Nanoparticles as Delivery Vehicles for Dual Tyrosine Kinase Inhibitor ZD6474 for Metastatic Breast Canc
✓ Rajesh Y., Biswas A. , Mandal M., Glioma progression through the prism of heat shock protein mediated extracellular matrix remodeling and epithelial to mesenchymal transition, Exp Cell Res., 2017
✓ Sohail S., Jaffery J. A., Biswas K., Jigsaw electrode design for electrowetting devices, Micro & Nano Letters, 1046-4059, 2018
✓ Sau M. C., Rajesh Y. , Mandal M. , Bhattacharjee M., Copper Catalyzed Regioselective N Alkynylation of Pyrazoles and Evaluation of the Anticancer Activity of Ethynyl Pyrazoles, Chemistryselect, 3511-3515, 2018
✓ Biswas S., Rajesh Y. , Barman S. , Bera M. , Paul A. , Mandal M. , Pradeep N. D., A dual-analyte probe: hypoxia activated nitric oxide detection with phototriggered drug release ability, Chem Commun, 7940-7943, 2018
✓ Mandal S. M., Sinha T. K., Katiyar A. K., Das S. , Mandal M. , Ghosh S., Existence of Carbon Nanodots in Human Blood, J Nanosci Nanotechnol, 6961-6964, 2019
✓ Rajesh Y., A B. , U K. , S D. , Banerjee I. , Banik P. , Bharti R. , Nayak S. , Ghosh S. K., Mandal M, Targeting NFE2L2, a transcription factor upstream of MMP-2: A potential therapeutic strategy for temozolomide resistant glioblastoma, Biochem Pharmacolo
✓ Pradeep N. D., Chaudhuri A. , Yarra . , Jena . , Behara . , Mandal M., Real-time monitoring of photo-activated hydrogen persulfide donor for biological entities, Org. Biomol. Chem, 2019
✓ Bharadwaj D., Mandal M., Senescence in Polyploid Giant Cancer Cells: A Road That Leads to Chemoresistance, Cytokine Growth Factor Rev, 52, 68-74, 2020
✓ Rajesh Y., Biswas A. , Kumar U. , Banerjee I. , Das S. , Maji S. , Das S. K., Emdad L. , Cavenee W. K., Mandal M. , Fisher P. B., Lumefantrine, an Antimalarial Drug, Reverses Radiation and Temozolomide Resistance in Glioblastoma, Proceedings of the Natio
✓ Ganguly S., Das P. , Das T. K., Ghosh S. , Das S. , Bose M. , Mandal M. , Das A. K., Das N. C., Acoustic cavitation assisted destratified clay tactoid reinforced in situ elastomer-mimetic semi-IPN hydrogel for catalytic and bactericidal application, Ultra
✓ Rajesh Y., Biswas A. , Banik P. , Pal I. , Das S. , Borkar S. A., Sardana H. , Saha A. , Das S. K., Emdad L. , Fisher P. B., Mandal M., Transcriptional regulation of HSPB1 by Friend leukemia integration-1 factor modulates radiation and temozolomide resist

✓ Involvement of Functional Single Nucleotide Polymorphisms (SNP) of Matrix Metalloproteinase (MMP) Gene Promoters in the Cell Type Specific Regulation of Human MMPs: Intrinsic Genetic Characteristics in Cancer Cell Progression
✓ Unravelling Cancer Transformation and Progression through Biological, Electro-mechanical and Computational Techniques
✓ Natural Silk Protein based Modification of Orthopaedic Implant to improve Osteogenesis and Osseo-integration
✓ Delivery of Drugs and Cells to the Cornea using Silk Protein - A Novel Therapeutic Approach
✓ Combining Metformin and Metronomic Liposomal Chemotherapeutic Formulation for Effective Management of Multiple Cancers
✓ Pilot Scale Study on Local Inhabitants Reduction of Fear to AAI Programme as Par Demand of Local Administration
✓ Development of Dense and Porous Titanium Components via Powder Metallurgy Route for Biomedical Applications
✓ Signals & Systems for Life Science
✓ Engineered silk matrices for optimization of in vitro 3D tumour model
✓ Dealing with the Cancer of Cervix: Enhancing the Efficacy of Ionizing Radiation with Gold Nanoparticle

✓ J C Bose National Fellow
✓ FNSc
✓ FNASc
✓ FNA
✓ FAScT

A Process for the Purification of a New Motility-promoting Protein from Buffalo Serum: A Slaughter House Waste
Anti-Bacterial Hydrogel Composition and Application Thereof, India, 2013
Selective Leukapheresis. System for Cytoreduction of Circulating Cancer Cells from Blood and a Method Thereof, India, 2015

Cancer Biology