Koel Chaudhury

Thu, 4 Dec 2025 - 05:50

mypanel

Designation

Professor

Email

koel@smst.iitkgp.ac.in

The Clinical Biomarkers Discovery Laboratory is actively involved in using the newly emerged field of metabolomics, which iscapable of providing biological end-point markers of the cellular processes that occur as a result of the disease. Metabolomics has rapidly evolved during recent years and is complementary to different? omics? technologies, such as transcriptomics and proteomics. We focus on the use of metabolomics for comprehensive identification of disease biomarkers and understanding of the pathogenic mechanism underlying complex human diseases. We have extensively used the metabolomics approach to investigate Women's health with an emphasis on pregnancy-related complications. Early-stage biomarkers specific to Stage I and Stage II endometriosis have been successfully identified and validated. The design of a biochemical sensor based on these findings is underway. Biomarkers for gestational hypertension, recurrent miscarriage, polycystic ovarian syndrome (PCOS), and female dormant genital tuberculosis are also being explored. Recently, our team has initiated work in the area of Respiratory health. We are using metabolomics for the identification of unique metabolic fingerprints in exhaled breath condensates and serum for differentiating the various endotypes/sub-types of asthma and chronic obstructive pulmonary disease (COPD). Dysregulated glucose and lipid metabolism intermediates and amino acid changes between the sub-types have been identified. We are also profiling other respiratory disorders including interstitial lung disease (ILD), pulmonary hypertension, and lung cancer with an aim to enhance the scope for novel point of care device development.

Research Areas:

Non-invasive Biomarkers and Sensors

Metabolomics

Nanomedicine

Women's Health

Respiratory Disorders

✓ Naskar D., Sapru S. , Li Z. , Yang X. , Mandal M. , Ghosh A. K., Kundu S. C., Non-mulberry silk fibroin based nerve guide biomaterials for neural tissue engineering, European chapter meeting TERMIS, Upsala, Sweden, 2016
✓ Das D., Anura A. , Das S. , Mandal M. , Das S, AFM based Biomechanical Characterization for Assessment of Cancer Aggressiveness, Biophysical Society Conference: Mechanobiology of Disease, 2016
✓ Sapru S., Mandal M. , Ghosh A. K., Kundu S. C., Antibacterial nanofibrous matrices of non-mulberry silk sericin for wound repair, TERMIS-AM Annual conference and Exhibition, 2016
✓ Biswas A., Yetirajam R. , Das S. , Parekh A. , Mandal M., Targeting ECM via stress associated regulation: A potential therapeutic avenue for overcoming temozolamide resistance in glioblastoma, European Congress on Biotechnology, 2018
✓ Das C. K., Jena B. C., Das S. , Parekh A. , Dey G. , Bharti R. , Bharadwaj D. , Mandal M., Parkin-mediated mitophagy regulates 5-fluorouracil-induced chemoresistance in breast cancer, AACR Annual Conference 2018 at Chicago, USA, 1348-1348, 2018
✓ Bharadwaj, D., Parekh A. , Das S. , Jena B. C., Mandal M., Polyploid giant cancer cells induce growth arrest and cytoskeletal rearrangement in breast cancer cells, European Congress on Biotechnology, 2018
✓ Point of Care Application by Kare S. P., Das D. , Chaudhury K. , Das S., Fabrication of Cost-effective and Lithographically Patterned Flexible Paper-based Microfluidic Device using Photo-PDMS for Point of Care Application, 26th Anniversary World Congress
✓ Chaudhury K., Roychoudhury S. , Joshi M. , Chakravarty B., Serum metabolic signatures differentiate women with repeated embryo implantation failure from recurrent implantation success, International Conference of the Metabolomics Society, 2018
✓ Chaudhury K., Choudhury P. , Ghosh N. , Joshi M. , Bhattacharyya P, NMR serum metabolomics for understanding the pathophysiology of COPD associated PH: A pilot study, European Respiratory Society Congress, 2018
✓ Bhattacharya N. S., Manchikanti P. , Chaudhury K., Manufacturing of biodrugs, BioDrugs, 217-229, 2009
✓ DUTTA, M., JOSHI, M., SRIVASTAVA, S., LODH, I., CHAKRAVARTY, B. & CHAUDHURY, K., A metabonomics approach as a means for identification of potential biomarkers for early diagnosis of endometriosis, Mol. Biosyst, 2012
✓ SINGH, A. K., CHATTOPADHYAY, R., CHAKRAVARTY, B. & CHAUDHURY, K., Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF, Reprod. Toxicol, 116-124, 2013
✓ BANERJEE, P., DUTTA, M., SRIVASTAVA, S., JOSHI, M., CHAKRAVARTY, B. &CHAUDHURY, K, H NMR serum metabonomics for understanding metabolic dysregulation in women with idiopathic recurrent spontaneous miscarriage during implantation window, J Proteome Res, 13
✓ Ghosh S., Pandey N. K., Banerjee P. , Chaudhury K. , Nagy N. V., Dasgupta S, Copper(II) directs formation of toxic amorphous aggregates resulting in inhibition of hen egg white lysozyme fibrillation under alkaline salt mediated conditions, J. Biomol. Stru
✓ DUTTA, M., SUBRAMANI, E., TAUNK, K., GAJBHIYE, A., SEAL, S., PENDHARKAR, N., DHALI, S., RAY, C. D., LODH, I., CHAKRAVARTY, B., DASGUPTA, S., RAPOLE, S.,CHAUDHURY, K, Investigation of serum proteome alterations in human endometriosis, J Proteomics, 114, 18
✓ ROYCHOUDHURY S, SINGH A, GUPTA NJ, SRIVASTAVA S, JOSHI MV, CHAKRAVARTY B, CHAUDHURY K, Repeated implantation failure versus repeated implantation success: discrimination at a metabolomic level, Hum Reprod, 1265-1274, 2016
✓ SUBRAMANI E, DUTTA M, JOTHIRAMAJAYAM M,JOSHI M, SRIVASTAVA S, MUKHERJEE A, CHAKRAVARTY BN, CHAUDHURY K., Identification of serum metabolic markers for diagnosis of women with dormant genital tuberculosis, Metabolomics, 2016
✓ GHOSH N, DUTTA M, SINGH B, BANERJEE R, BHATTACHARYYA P, CHAUDHURY K, Transcriptomics, proteomics and metabolomics driven biomarker discovery in COPD: an update, Expert Rev Mol Diagn, 16, 897-913, 2016
✓ A., Dabhi R. , Taunk K. , Jagadeeshaprasad M. G., Roychoudhury S. , Mane A. , Bayatigeri S. , Chaudhury K. , Santra M. K., Rapole S., Multipronged quantitative proteomics reveals serum proteome alterations in breast cancer intrinsic subtypes, Journal of P
✓ Ray S., Dutta M. , Chaudhury K. , De B., GC MS based metabolite profiling and angiotensin I-converting enzyme inhibitory property of black tea extracts, RevistaBrasileira de Farmacognosia, 27, 580-586, 2017
✓ T. H., Bagadi M. , Roychoudhury S. , Dutta M. , Uppal A. , Mane A. , Santra M. K., Chaudhury K. , Rapole S., Comprehensive quantitative lipidomic approach to investigate serum phospholipid alterations in breast cancer, Metabolomics, 2017
✓ Singh B., Jana S. K., Ghosh N. , Das S. K., Joshi M. , Bhattacharyya P. , Chaudhury K., Metabolomic profiling of doxycycline treatment in chronic obstructive pulmonary disease, Journal of Pharmaceutical and Biomedical Analysis, 132, 103-108, 2017
✓ Bunkar N., Bhargava A. , Chaudhury K. , Sharma R. S., Lohiya N. K., Mishra P. K., Fetal nucleic acids in maternal plasma: from biology to clinical translation, Frontiers in bioscience, 23, 397-431, 2018
✓ Siddiqa A. J., Maji S. , Chaudhury K. , Adhikari B., A facile route to develop hydrophilicity on the polyolefin surface for biomedical applications, Advances in Polymer Technology, 37, 1410-1419, 2018
✓ Singh R., Shandilya R. , Bhargava A. , Kumar R. , Tiwari R. , Chaudhury K. , Srivastava R. , Goryacheva I. , Mishra P., Quantum dot based nano-biosensors for detection of circulating cell free miRNAs in lung carcinogenesis: from biology to clinical transl
✓ Rameshbabu A., Datta S. , Bankoti K. , Subramani E. , Chaudhury K. , Lalzawmliana V. , Nandi S. , Dhara S., Polycaprolactone nanofibers functionalized with placental derived extracellular matrix for stimulating wound healing activity, Journal of materials
✓ Dutta M., Singh B. , Joshi M. , Das D. , Subramani E. , Maan M. , Jana S. K., Sharma U. , Das S. , Dasgupta S. , Ray C. D., Chakravarty B. , Chaudhury K, Metabolomics reveals perturbations in endometrium and serum of minimal and mild endometriosis, Scient
✓ Singh B., Ghosh N. , Saha D. , Sarkar S. , Bhattacharyya P. , Chaudhury K., Effect of doxycyline in chronic obstructive pulmonary disease-An exploratory study, Pulmonary pharmacology & therapeutics, 2019
✓ Ghosh S., Raju R. , Ghosh N. , Chaudhury K. , Ghosh S. , Banerjee . , Pramanik, Development and physicochemical characterization of doxorubicin-encapsulated hydroxyapatite polyvinyl alcohol nanocomposite for repair of osteosarcoma-affected bone tissues, C
✓ Shukla ., Bunkar N. , Kumar R. , Bhargava A. , Tiwari R. , Chaudhury K. , Goryacheva I. , Mishra P., Air pollution associated epigenetic modifications: Transgenerational inheritance and underlying molecular mechanisms, Science of the total environment, 65
✓ Bhargava A., Shukla A. , Bunkar N. , Shandilya R. , Lodhi L. , Kumari R. , Gupta P. K., Rahman A. , Chaudhury K. , Tiwari R. , Goryacheva I. Y., Mishra P. K., Exposure to ultrafine particulate matter induces NF- mediated epigenetic modifications, Environ

✓ Design Food Formulation with Resistant Starch and Protein for Diabetic / Nephro-diabetic Patients: An Approach Towards Commercialization
✓ Aberrant Circulation Epigenomic Signatures: Development and Validation of Non-invasive Biomarkers for Trans-generational Monitoring of Air Pollution Associated Cancers
✓ A Carbon Nanotube-based Miniaturized Sensor for Differential Diagnosis of Aco form Asthma and COPD
✓ National Centre for Technology in Family Welfare (NCTFW)

✓ Technology Innovation
✓ Labhsetwar award

Biodegradable Polymer Encapsulated Besifloxacin Nanoparticles, India, 2014

Biosensors

Sanjukta Dasgupta

Research Scholars

Ph.D

Respiratory health