Gayatri Mukherjee
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Emailgayatri.mukherjee@smst.iitkgp.ac.in
Ours is an Immunology laboratory that is interested in teasing out the intricacies of immune response and immune tolerance. To that end, we are interested in deciphering the molecular pathways that help maintain the balance between immune response and immune tolerance and utilize that knowledge to better understand autoimmune disease pathogenesis and cancer development.
Immunotherapy is the technique of utilizing one’s own immune system to treat various diseases by inducing, enhancing or suppressing an immune response. The final goal of immunotherapy is to be able to manipulate pertinent immune system components without disturbing the rest. Manipulation of a cellular compartment such as T cells in its entirety or systemic manipulation of immunogical pathways such as costimulatory molecules leads to deleterious side effects like rendering the individual immunocompromised. Therefore, targeted immunotherapeutic strategies which deal with specific cell populations instead of such big-hammer approaches, should be the way forward for the field. Conforming to that idea, we are working to develop T cell-based novel immunotherapeutic strategies in cancer and autoimmunity with the ultimate goal of the development of personalized medicine.
Research Areas:
- ✓ Mukherjee G, Dilorenzo TP, The immunotherapeutic potential of dendritic cells in type 1 diabetes., Clin. Exp. Immunol, 161, 2010
- ✓ Samanta D*, Mukherjee G*, Ramagopal UA, Chaparro RJ, Nathenson SG, DiLorenzo TP, Almo SC, Structural and functional characterization of a single-chain peptide-MHC molecule that modulates both naive and activated CD8+ T cells, Proc. Natl. Acad. Sci. U S A,
- ✓ Chakraborty DC, Mukherjee G, Banerjee P, Banerjee KK, Biswas T., Hemolysin induces Toll-like receptor (TLR)-independent apoptosis and multiple TLR-associated parallel activation of macrophages, J. Biol. Chem, 286, 2011
- ✓ Antal Z, Baker JC, Smith C, Jarchum I, Babad J, Mukherjee G, Yang Y, Sidney J, Sette A, Santamaria P, DiLorenzo TP., HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes.,
- ✓ Prakash RK, Samanta D, McPhee CG, Kay TWH, Almo SC, DiLorenzo TP, Serreze DV, Compensatory mechanisms allow undersized anchor-deficient Class I MHC ligands to mediate pathogenic autoreactive T-cell responses, J Immunol, 193, 2014
- ✓ Mukherjee G, Geliebter A, Babad J, Santamaria P, Serreze DV, Freeman GJ, Tarbell KV, Sharpe A, Dilorenzo TP, DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8+ T cells independently of PD-1 and PD-L1,
- ✓ Chaparro RJ, Schloss C, Smith C, Bando CD, Glucagon-reactive islet infiltrating CD8 T cells in NOD mice, Immunology, 144, 2015
- ✓ Babad J, Mukherjee G, Follenzi A, Ali R, Shultz L, Santamaria P, Yang O, Roep B, Goldstein H, Greiner D, DiLorenzo TP, Generation of ? cell-specific human T cells by lentiviral transduction and their survival in immunodeficient HLA-transgenic mice, Clin.
- ✓ Katakowski JA, Mukherjee G, Wilner SE, Maier K, Harrison MT, DiLorenzo TP, Levy M, and Palliser D, Delivery of siRNAs to dendritic cells using DEC205-targeted lipid nanoparticles to inhibit immune responses, Mol. Ther, 2016
- ✓ Chakrabarti R., Kapse B. , Mukherjee G, Soluble immune checkpoint molecules: Serum markers for cancer diagnosis and prognosis, Cancer reports, 2019
- ✓ Development of Cell-free Peptide-MHC Based Immunotherapeutic Reagent to Manipulate Cytotoxic T Cells in Cancer
- ✓ MHC Haplotypes in HBE / Beta Thalassemia: Correlating Disease Heterogeneity and Blood Transfusion Requirements in West Bengal
- ✓ Development of Antigen specific Cell-free and Cell-based Novel Immunotherapeutic Strategies in Cancer
- ✓ BTNL2, a Novel T Cell Coinhibitory Molecule, as a Therapeutic Target in Ulcerative Colitis
- ✓ Best presentation award in a seminar series during M.S., Presidency College, Kolkata
- ✓ Qualified the Joint University Grant Commission (UGC)–Council for Scientific and Industrial Research (CSIR), National Eligibility Test
- ✓ Qualified the Graduate Aptitude Test Examination conducted by the Indian Institute of Technolo
- ✓ UGC-Junior Research Fellowship
- ✓ UGC-Senior Research Fellowship
- ✓ Best Poster award at Dennis Shields Post-Doctoral Award Symposium, Albert Einstein College of Medicine
- ✓ AAI Trainee Abstract Award at IMMUNOLOGY, Annual Meeting of The American Association of Immunologists. Pittsburgh, PA, USA
Patents will be updated soon.
Anita Hansda
Research Scholars
Ph.D
Immunology
Debangshu Mukherjee
Research Scholars
Ph.D
Immunology
Debarati Biswas
Research Scholars
Immunology
Dhrubajyoti Mahata
Research Scholars
Ph.D
Immunology
Krishna Dixit
Research Scholars
Ph.D
Tissue Enginnering
Rituparna Chakrabarti
Research Scholars
Ph.D
Immune system involvement in cardiac and vascular remodeling
Sanjukta Dasgupta
Research Scholars
Ph.D
Respiratory health